New Recommendations Aim to Redefine Definition and Enhance Diagnosis of Sepsis, Septic Shock

In a series of articles published last month in JAMA and released during the 45th Critical Care Congress, an international task force updated definitions of sepsis and septic shock. The group’s recommendations not only advance new definitions for sepsis and septic shock, but also offer clinical guidance to help physicians more quickly identify patients with or at risk of developing sepsis.
At present, The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), has more than 560,000 views, making it one of the best viewed JAMA articles of all time.
Accompanying articles by Seymour et al and Angus et al published in Critical Care Medicine also present a conceptual framework to help patients, clinicians, researchers and hospitals apply the new definitions. The Society has also released SCCM Pod-311 New Sepsis Definitions: An In-Depth Interview with Craig Coopersmith to help give context to the new definitions.
“This is an incredibly exciting time in the field of sepsis,” said Craig M. Coopersmith, MD, FCCM, a task force member and immediate past president of the Society. “Driven by a combination of data analysis on well over one million patients as well as expert consensus, these new definitions provide a real step forward.”
The task force definitions were directly informed by research out of the Clinical Research, Investigation, and Systems Modeling of Acute illness (CRISMA) Center at the Pitt School of Medicine and were funded in part by grants from the National Institutes of Health. They were sponsored by more than 30 organizations representing a variety of professionals who manage and diagnose sepsis.